Benchling Acquires PipeBio

Identify antibody liabilities and PTMs

De-risk antibody development by identifying sequence liabilities and flagging sequence motifs of residues that may give rise to PTMs and affect the structure and function antibody candidates.

Antibody hit expansion and data mining

Use PipeBio for mining NGS repertoires for expanding potential hit sequences of characterized antibody sequences

Analyze NGS from antibody library, repertoire sequencing and panning

Annotate and cluster NGS data from biopanning experiments and find differentially enriched sequence clusters across multiple panning rounds.

Identify enriched and diverse antibodies with good binding properties

Add functional assay data, such as ELISA, FACS and other immunoassay data and use built-in tools to identify the most diverse antibodies for synthetization and characterization

Easy Sanger analysis

Trim, assemble forward and reverse reads, detect heterozygous peaks, annotate, edit and align Sanger sequences

Calculate protein properties and show hydrophobic regions

Use built-in tools to calculate charge, isoelectric point (pI), molecular weight and identify hydrophobic regions in your antibody or peptide sequences

Predict antibody structure

Predict antibody (VH-VH from IgG) or nanobody (VHH) structures and obtain .PDB files for predicted structures.

Sequence editing editing, codon optimization

Bulk clone many insert fragments in one simple operation, Identify problematic internal cut sites, edit your sequences in-line in the editor, export to excel, genbank, QPIX.