Benchling has acquired PipeBio!

the

Bioinformatics Cloud
for Scientists

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Working with scientists from academia to top 10 pharma

Our platform

For Scientists and Bioinformaticians

PipeBio is a cloud-based bioinformatics software for BCR, TCR, VHH, scFv or peptide sequence analysis.

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From repertoire to hit list

Automate workflows to identify candidate sequences from large-scale NGS antibody repertoires, hybridoma sequencing, clonal expansion in biopanning experiments or identify liabilities and assess antibody developability.

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Sequence database and storage

Store your antibody sequences in a central database, associate metadata, such as target specificity, binding affinity, and compare sequences from new experiments with sequences found in your database or public databases.

Database capabilities

Automated workflows and integration

Configure end-to-end workflows on PipeBio, integrate with your ELN, LIMS, internal tools and build entire automated pipelines with our REST API.

Workflows and integration

Analyze NGS and Sanger sequences fast and reliably on PipeBio

Features

Annotate and identify liabilities in your sequences

Identify FRs, CDRs, mutations through germline alignments for antibody formats like IgG, scFv, VHH and TCRs or other custom scaffolds for any species. Detect sequence-based liabilities. Align sequences to identify conserved residues and variability.

Annotation and liabilities

Clustering and comparing samples

Cluster by defining your clonotype, identify clonal families and compare samples across experiments, analyze enrichment and explore clusters visually with cluster network plots.

Clustering and comparison

Visualize with charts

Use interactive charts to visualize sequence clusters, amino acid frequencies, codons and genes, sequence quality, phylogeny of antibody clones etc.

Visualization

Analysis with functional assay data and hit picking

Associate your functional assay data or metadata with sequences and analyze protein properties, ELISA, structural liabilities, transcriptomics and hit pick your

Hit picking and metadata

Antibody engineering

Edit your sequences on a nucleotide or protein level, use our antibody engineering tools to calculate protein properties, optimize degenerate codons for synthesis, analyze hydrophobicity of sequences and more.

Antibody engineering